参考文献

流行病学

[1]Collazos J. CNS Drugs. 2003;17:869.
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[2]Iyer RS, Banker DD. Indian J Med Sci. 2002;56:593.
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[3]Lakshmi V, Sudha T, Teja VD, et al. Indian J Med Microbiol. 2007;25:146
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[4]卢洪洲,曹天高,周颖杰,等.乳胶凝集试验对新型隐球菌性脑膜炎诊断及治疗的意义.中华传染病杂志,2005,23(3):209
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病因

[1]Casadevall A, Perfect JR. Cryptococcus neoforman [M]. Washington DC: ASM Press. 1998,41-70.

病理解剖

[1]王维治. 神经病学. 第1版. 676-677.

病理生理

[1]Baker RD. The primary pulmonary lymph node complex of cryptococcosis. Am J Clin Pathol.1976;65:83-92.
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[2]Chrerien F, Lortholary O, Kansau I, et al. Pathogenesis of cerebral Cryptococcus neoformanns infection after fungemia. J Infect Dis. 2002;186(4):522-530。
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[3]Bose I,Reese AJ,Ory JJ,Janbon G,Doering TL. A yeast under cover: the capsule of Cryptococcus neoformans. Eukaryot Cell. 2003 Aug. 2(4): 655-63.
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[4]Cox GM,McDade HC,Chen SC,Tucker SC,Gottfredsson M,Wright LC,Sorrell TC,Leidich SD,Casadevall A,Ghannoum MA,Perfect JR. Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans. Mol Microbiol. 2001 Jan. 39(1): 166-75.
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[5]D'Souza CA,Alspaugh JA,Yue C,Harashima T,Cox GM,Perfect JR,Heitman J. Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Mol Cell Biol. 2001 May. 21(9): 3179-91.
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[6]Ambrose YJ,Wu CH, J iang S, et al. HIV21 gp41 ectodomain enhances. Cryptococcus neoform ans binding to HBMEC biochemical and biophysical. Research Communications. 2007;356(3):8992905.

预防

[1]Devi SJ, Scheerson R, Egan W, et al. Cryptococcus neoformans serotype A glucuronoxylomannan protein conjugate vaccines: synthesis,characterization, and immunogenicity. Infect Immunol. 1991;59:3700-7.
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诊断标准

[1]王维治. 神经病学. 2006年第1版,677.

治疗细则

[1]Saag MS,Graybill RJ,Larsen RA,Pappas PG,Perfect JR,Powderly WG,Sobel JD,Dismukes WE. Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America. Clin Infect Dis. 2000 Apr. 30(4): 710-8.
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[2]Macsween K, Bicanic T, Brouwenr AE, et al. Harrison TS. Lumbar drainage in control of cerebrospinal fluid pressure in cryptococcal meningitis: Case report and review. J Infect. 2005,inpress.
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[3]Park MK, Hospenthal DR, Bennett JE. Treatment of hydrocephalus secondary to cryptococal meningitis by use of shunting. Clin Infect Dis. 1999;28:629-633.
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[4]Perfect JR, Dismukes WE, Dromer F, et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious disease society of America. Clin Infect Dis. 2010;50(3):291-322.
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[5]Casadevall A, Cleare W, Feldmesser M . Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies. Antimicrob Agents Chemother. 1998;42:1437-46.
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[6]Pappas PG,Bustamante B,Ticona E,Hamill RJ,Johnson PC,Reboli A,Aberg J,Hasbun R,Hsu HH. Recombinant interferon- gamma 1b as adjunctive therapy for AIDS-related acute cryptococcal meningitis. J Infect Dis. 2004 Jun 15. 189(12): 2185-91.
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[7]Woods ML 2nd,MacGinley R,Eisen DP,Allworth AM. HIV combination therapy: partial immune restitution unmasking latent cryptococcal infection. AIDS. 1998 Aug 20. 12(12): 1491-4.
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预后

[1]Dismukes WE,Cloud G,Gallis HA,Kerkering TM,Medoff G,Craven PC,Kaplowitz LG,Fisher JF,Gregg CR,Bowles CA. Treatment of cryptococcal meningitis with combination amphotericin B and flucytosine for four as compared with six weeks. N Engl J Med. 1987 Aug 6. 317(6): 334-41.
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[2]Diamond RD, Bennett JE. Prognostic factors in cryptococcal meningitis. A study in 111 cases. Ann Intern Med.1974;80:176-181.
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[3]Brouwer AE, Rajanuwong A, Chierakul W, et al. Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial. Lancet.2004;363:1764-1767.
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[4]Mirza SA, Phelan M, Rimland D. The changing epidemiology of
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[5]Imwidthaya P, Poungvarin N. Cryptococcosis in AIDS. Postgrad Med J.2000;76:85-88.
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[6]Larsen RA, Bauer M, Thomas AM, et al.Amphotericin B and fluconazole, a
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[7]White M, Cirrincione C, Blevins A, et al. Cryptococcal meningitis with AIDS and patients with neoplastic disease. J Infect Dis. 1992;165:960-6.
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[8]Husain A, Wagener MM, Singh N. Cryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcome. Emerg Infect Dis.2001;7:375-81.
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[9]Seaton RA, Naraqi S, Wembri JP, et al. Predictors of outcome in Cryptococcus neoformans var. gattii meningitis. Q J Med.1996;89:423-8.
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